Handbook of Epilepsy Treatment, 3rd Edition

Acknowledgements.

1 Definitions and Epidemiology.

Definitions.

Frequency and population features of epilepsy.

2 Seizure Type and Anatomical Location of Seizures.

Seizure type.

Classifi cation of partial seizures by anatomical site of seizure onset.

3 Epilepsy Syndromes.

ILAE Classifi cation of the Epilepsies and Epilepsy Syndromes.

The epilepsy syndromes.

4 The Causes of Epilepsy.

Idiopathic epilepsy.

Symptomatic epilepsy of genetic or congenital origin.

Symptomatic epilepsy due to acquired causes.

Provoked seizures.

5 Principles of Treatment.

Why treat epilepsy? The aims of treatment.

The risks of epilepsy and its treatment.

Choice of antiepileptic drug therapy based on seizure type.

Treatment of specifi c epilepsy syndromes.

Principles of treatment of newly diagnosed patients.

Principles of treatment of patients with established active epilepsy.

Treatment of patients with epilepsy in remission.

Psychiatric disorders in epilepsy.

Life-threatening idiosyncratic reactions.

Complementary and alternative therapy in epilepsy.

Genetic counselling in epilepsy.

6 Treatment of Epilepsy in Specifi c Groups.

Treatment of epilepsy in children.

Treatment of epilepsy in patients with additional handicaps.

Epilepsy in elderly people.

Treatment of epilepsy in women.

7 Pharmacokinetic Principles of Antiepileptic Drug Treatment.

Drug absorption.

Drug distribution.

Drug elimination (metabolism and excretion).

Blood level measurements.

8 The Antiepileptic Drugs.

Carbamazepine.

Clobazam.

Clonazepam.

Eslicarbazepine acetate.

Ethosuximide.

Gabapentin.

Lacosamide.

Lamotrigine.

Levetiracetam.

Oxcarbazepine.

Phenobarbital.

Phenytoin.

Pregabalin.

Primidone.

Rufi namide.

Tiagabine.

Topiramate.

Valproate.

Vigabatrin.

Zonisamide.

Other drugs used in the treatment of epilepsy.

Acetazolamide.

Benzodiazepines.

Corticosteroids and ACTH.

Felbamate.

Piracetam.

Stiripentol.

9 The Emergency Treatment of Epilepsy.

How to deal with a seizure.

Status epilepticus.

Antiepileptic drugs used in status epilepticus.

10 The Surgical Therapy of Epilepsy.

Presurgical assessment – general points.

Surgery in epilepsy arising in the mesial temporal lobe.

Surgery in epilepsy arising in extratemporal regions and the temporal neocortex.

Cortical dysplasia (malformations of cortical development).

Surgery where no lesion is apparent on neuroimaging ('MRI-negative cases')

Hemispherectomy, hemispherotomy and other large resections.

Corpus callosectomy (corpus callosum section, corpus callosotomy).

Multiple subpial transection.

Vagal nerve stimulation.

Other functional surgical procedures.

The organization of epilepsy surgery care: the epilepsy surgery centre.

Pharmacopoeia.

Antiepileptic drugs – indications in epilepsy.

Antiepileptic drugs – dose, average adult values.

Antiepileptic drugs – dose, interactions.

Antiepileptic drugs – dose, in children.

Antiepileptic drugs – summary of side effects.

Antiepileptic drugs – summary of metabolism.

Antiepileptic drugs – summary of pharmacokinetic values (typical adult values).

Antiepileptic drugs – modes of action.

Further Reading.

Index.