Chronopharmaceutics: Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

"[This book] has the challenging subtitle "Science and technology for biological rhythm-guided therapy and prevention of diseases", which recognizes the fact, ignored by those developing pharmaceuticals, that one can also seek specific times when certain chemical structures best achieve their desired effects with least undesired consequences.... The book is recommended to all who deal with pharmaceutics, as well as with pharmacology. As noted by Bi-Botti C. Youan, whose milestones date back to the 7th century BCE, it should be part and parcel of the education of all health care providers and recipients. It could stem enormous current waste by those who have not yet acquainted themselves with phase-zero trials. Therein, timing takes first rather than last priority, as is currently the case in industry. By systematically testing new drugs at different rhythm stages at the outset, one may not only avoid discarding a useful drug if tested at the wrong time, but one may also obtain an estimate of what optimal rhythm stages may be, and assess the extent of difference in response from administering the drug at the presumably best or worst times."
—Franz Halberg, M.D., Dr. h.c. (mult.), Halberg Chronobiology Center University of Minnesota