What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd Edition

Answers the questions: What are the best tests? What controls should be used? How do you avoid potential hidden pitfalls, false positives and negatives, and lurking artifacts? Which statistical tests can be applied?

Includes a new chapter on Developmental and Neurodegenerative Diseases, covering mental retardation and inborn errors of metabolism through to Alzheimer's disease and stroke

Provides brand new coverage of practical recommendations for choosing tasks to evaluate a new mutant line (Putting It All Together), including complete guidelines for high-throughput screening

Discusses implications of the completion of the mouse genome sequence, microarray technology, new gene delivery methods, stem cell transplantation, proteomics, and high throughput approaches in chemical mutagenesis studies

Expands discussion to the latest studies in learning and memory, autism and social phobias, olfaction, drug addiction, withdrawal, and spinal cord injury

Includes numerous new figures showing new behavioral tests, equipment, and data

Each chapter concludes with extensive, up-to-date references and suggestions for background reading