Molecular Cancer Therapeutics: Strategies for Drug Discovery and DevelopmentISBN: 978-0-471-43202-9
Hardcover
368 pages
April 2004
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Molecular Cancer Therapeutics covers state-of-the-art
strategies to identify and develop cancer drug target molecules and
lead inhibitors for clinical testing. It provides a thorough
treatment of drug target discovery, validation, and development.
The introductory chapters provide an overview of pathways to
discovery and development of molecular cancer therapeutics.
Subsequent chapters progress from initial stages of drug target
discovery to drug discovery, development, and testing in
preclinical and clinical models. Topics include drug lead
screening, drug-to-lead development, proof-of-concept studies,
medicinal chemistry issues, intellectual property concerns, and
clinical development.
This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.
This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.