Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

ISBN: 978-0-471-43202-9

Hardcover

368 pages

April 2004

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Preface.

Contributors.

Chapter 1. Introduction (G. Prendergast).

Chapter 2. Molecular Cancer Therapeutics: Will the Promise Be Fulfilled? (B. Teicher).

Chapter 3. Cancer Genetics and Drug Target Selection (G. Zhang & W. Kaelin).

Chapter 4. RNA Interference in Mammals: Journey to the Center of Human Disease (P. Paddison & G. Hannon).

Chapter 5. Applications and Issues for Tissue Arrays in Target and Drug Discovery (E. Jonasch, K. Do, C. Logothetis, & T. McDonnell).

Chapter 6. Protein Transduction Strategies for Target and Mechanism Validation (S. Ezhevsky & S. Dowdy).

Chapter 7. Drug Screening: Assay Development Issues (S. Carroll, J. Inglese, S. Mao, & D. Olson).

Chapter 8. Gene Microarray Technologies for Cancer Drug Discovery and Development (R. te Poele, P. Clarke, & P. Workman).

Chapter 9. Transgenic Mouse Models of Cancer (T. Bowen & A. Wynshaw-Boris).

Chapter 10. Transgenic versus Xenograft Mouse Models of Cancer: Utility and Issues (M. Liu, W. Bishop, Y. Wang, & P. Kirschmeier).

Chapter 11. Pharmacodynamic Assays in Cancer Drug Discovery: From Preclinical Validation to Clinical Trial Monitoring (R. Lobell, N. Kohl, & L. Sepp-Lorenzino).

Chapter 12. Pharmacokinetic and Toxicology Issues in Cancer Drug Discovery and Development (P. Benfield & B. Car).

Chapter 13. Clinical Development Issues (S. Averbuch, M. Wolf, B. El-Rayes, & P. LoRusso).

Chapter 14. Intellectual Property and Commercialization Issues in Drug Discovery (L. Malseed).

Index.