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Drug Discovery and Development, Volume 1: Drug Discovery

ISBN: 978-0-471-39848-6
Hardcover
476 pages
June 2006
List Price: US $166.50
Government Price: US $115.16
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Drug Discovery and Development, Volume 1: Drug Discovery (0471398489) cover image

Contributors.

Preface.

1. From Patent to Prescription: Paving the Perilous Path to Profit (Richard J. Pariza).

2. Medicinal Chemistry in the New Millennium: A Glance into the Future (Paul W. Erhardt).

ADMET-Related Synergies, 59

3. Contemporary Drug Discovery (Lester A. Mitscher and Apurba Dutta).

4. Combinatorial Chemistry in the Drug Discovery Process (Ian Hughes).

5. Parallel Solution-Phase Synthesis (Norton P. Peet and Hwa-Ok Kim).

6. Timing of Analog Research in Medicinal Chemistry (János Fischer and Anikó Gere).

7. Possible Alternatives to High-Throughput Screening (Camille G. Wermuth).

8. Proteomics and Drug Discovery (Susan Dana Jones and Peter G. Warren).

Appendix: Public-Domain Software Tools and Databases.

9. Using Drug Metabolism Databases During Drug Design and Development (Paul W. Erhardt).

10. Discovery of the Antiulcer Drug Tagamet (C. Robin Ganellin).

11. Discovery of Potent Nonpeptide Vasopressin Receptor Antagonists (Bruce E. Maryanoff).

12. Discovery and Development of the Ultrashort-Acting Analgesic Remifentanil (Paul L. Feldman).

13. Discovery and Development of Nevirapine (Karl Grozinger, John Proudfoot, and Karl Hargrave).

14. Applications of Nuclear Imaging in Drug Discovery and Development (John W. Babich and William C. Eckelman).

15. Polymeric Sequestrants as Nonabsorbed Human Therapeutics (Pradeep K. Dhal, Chad C. Huval, and S. Randall Holmes-Farley).

16. Botanical Immunomodulators and Chemoprotectants in Cancer Therapy (Bhushan Patwardhan, Sham Diwanay, and Manish Gautam).

Index.
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