Biomedical Chemistry: Applying Chemical Principles to the Understanding and Treatment of Disease

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM FUNDAMENTALS OF ENZYME TRANSFORMATIONS AND MECHANISMS.

Sleeping Sickness: Irreversible Inhibitors of S-Adenosylmethionine Decarboxylase as Antitrypanosomal Agents (P. Woster).

Mechanism-Based S-Adenosyl-L-Homocysteine Hydrolase Inhibitors in the Search For Broad-Spectrum Antiviral Agents (D. Yin, et al.).

Alcoholism: Aldehyde Dehydrogenase Inhibitors as Alcohol Deterrent Agents (H. Nagasawa, et al.).

AIDS: Adenosine Deaminase-Activated Prodrugs for the Treatment of Huamn Immunodeficiency Virus in the Central Nervous System (J. Driscoll).

Anti-HIV Phosphotriester Pronucleotides: Basis for the Rational Design of Biolabile Phosphate Protecting Groups (C. Perigaud, et al.).

EXPLORATION OF FUNDAMENTAL CHEMICAL PRINCIPLES IN DRUG DESIGN AND DISCOVERY.

AIDS: Potential Inhibitors of Human Immunodeficiency Virus Replication (G. Kenyon).

From Chemical Warfare Agent to Anticancer Drug: The Chemistry of Phosphoramide Mustard (S. Ludeman).

Phosphoryltyrosyl Mimetics as Signaling Modulators and Potential Antitumor Agents (T. Burke, et al.).

Targeting Tumors Using Magnetic Drug Delivery (S. Pulfer & J. Gallo).

Cancer: Superacid Generation of New Antitumor Agents (J.-C. Jacquesy & J. Fahy).

Fluorine Substitution as a Modulator of Biological Processes (K. Kirk).

UNDERSTANDING THE CHEMICAL BASIS OF DRUG ACTION AND DISEASE.

Thiouracil and Related Thioureylene Compounds as Melanoma-Seekers: Paradigms for a Chemical Approach to the Design of Targeting Anticancer Agents (M. d'Ischia & G. Prota).

Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide Drugs (G. Posner, et al.).

The Chemistry of Parkinson's Disease (G. Dryhurst, et al.).

NOVEL CHEMISTRIES IN THE VANGUARD OF BIOTECHNOLOGY AND DRUG DISCOVERY.

New Generation of DNA Chips Based on Real-Time Biomimetic Recognition (F. Garnier).

Peptide Nucleic Acids (PNA): Towards Gene Therapeutic Drugs (P. Nielsen).

Ribozyme Mimics: The Evolution of Gene-Specific Chemotherapy (T. Osiek, et al.).

Index.