Six-Membered Transition States in Organic Synthesis

Introduction.

1 [3,3]-Sigmatropic Rearrangements.

General Considerations.

Reactions.

1.1 Claisen Rearrangement.

1.2 Johnson–Claisen Rearrangement.

1.3 Ireland–Claisen Rearrangement.

1.4 Cope Rearrangement.

1.5 Anionic Oxy-Cope Rearrangement.

1.6 Aza-Cope–Mannich Reaction.

2 Aldol Reactions.

General Considerations.

Reactions.

2.1 Asymmetric Syn-Aldol Reaction.

2.2 Asymmetric Anti-Aldol Reaction.

2.3 Proline-Catalyzed Asymmetric Aldol Reaction.

3 Metal Allylation Reactions.

General Considerations.

Reactions.

3.1 Boron Allylation Reaction.

3.2 Silicon Allylation Reaction.

4 Stereoselective Reductions.

General Considerations.

Reactions.

4.1 Diastereoselective Syn-Reduction of β-Hydroxy Ketones.

4.2 Diastereoselective Anti-Reduction of β-Hydroxy Ketones.

4.3 Asymmetric Reduction.

List of Copyrighted Materials.

Abbreviations.

Subject Index.

Scheme Index of Natural Products.