Six-Membered Transition States in Organic SynthesisISBN: 978-0-470-17883-6
Hardcover
224 pages
February 2008
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Fifty years ago, Zimmerman and Traxler put forth an audacious
suggestion that in a reaction they were studying six of the atoms
were oriented in a ring as the two components approached each
other. This was at a time when no one considered the detailed
orientation of molecules during reactions. This Zimmerman-Traxler
hypothesis is now known to be not only correct for their reaction,
but in fact true in many other chemical processes. As such, the
idea is one of the fundamental organizing principles of organic
chemistry. Yang (Montana State Univ.) has provided a useful
collection of all reactions currently understood to proceed in such
fashion. These reactions are contained in 4 chapters: "[3,3] -
Sigmatrophic Rearrangements," "Aldol Reactions," "Metal Allylation
Reactions," and "Stereoselective Reductions." This small book
should be useful for both synthetic chemists and those studying
mechanisms, particularly stereochemistry, of organic reactions.
Summing Up: Recommended. Upper-division undergraduate
through professional collections. -- A. Fry, Wesleyan
University (CHOICE, March 2009)
It is an interesting, well-written, and carefully researched book, full of useful details for practioners and students of organic chemistry. (Journal of the American Chemical Association, July 2, 2008)