Dopamine Transporters: Chemistry, Biology, and PharmacologyISBN: 978-0-470-11790-3
Hardcover
472 pages
July 2008
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This book consolidates current information on the dopamine
transporter (DAT) in relationto medicinal chemistry and synthesis,
biology and pathology, and pharmacology. Because of DAT's role in
diseases such as Parkinson's, schizophrenia, attention deficit
hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse
(in particular, cocaine addiction), DAT research is an exploding
field. Tremendous advances have been made toward understanding how
it impacts a variety of neurological disease states and
disorders.
This reference provides a broad overview of current knowledge that
is detailed enough to furnish a basic understanding of the
biological, chemical, and pharmacological aspects of DAT in one
comprehensive reference. With contributions from eminent scientists
who are experts in their particular areas, Dopamine
Transporters: Chemistry, Biology, and Pharmacology:
- Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization
- Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers
- Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods