Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery

Preface vii

Contributors ix

1. In the Beginning There Was Streptomycin 1
Julian Davies

2. The Biochemistry and Genetics of Aminoglycoside Producers 15
Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier

3. Mechanisms of Aminoglycoside Antibiotic Resistance 119
Tushar Shakya and Gerard D. Wright

4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics 141
Jinhua Wang and Cheng-Wei Tom Chang

5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181
R. Andrew Marshall and Joseph D. Puglisi

6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding a Sites Free and Complexed with Aminoglycosides 209
Jiro Kondo and Eric Westhof

7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225
Dale Kling, Christine Chow, and Shahriar Mobashery

8. Metalloaminoglycosides: Chemistry and Biological Relevance 235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan

9. Adverse Effects of Aminoglycoside Therapy 255
Andra E. Talaska and Jochen Schacht

10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267
Lev Elson-Schwab and Yitzhak Tor

11. Novel Targets for Aminoglycosides 289
Dev P. Arya, Nicholas Shaw, and Hongjuan Xi

Index 315