Thiophene and Its Derivatives, Volume 3

Preface vii

I. General Discussion 1

II. Biological and Pharmacological Activity of Thiophene and Its Derivatives 29
By F. F. Blicke

III. Synthesis and Physical Properties of Thiophene and Its Homologs 47

IV. Molecular Structure and Spectroscopy of Thiophene and Its Derivatives 81
By Frank P. Hochgesang

V. Factors Affecting Substitution Reactions in the Thiophene Nucleus 143

VI. Alkylation, Polymerization, Hydrogenation and Miscellaneous Reac­tions of Thiophene 159

VII. Halothiophenes and Haloalkylthiophenes 173

VIII. The Nitro-and Aminothiophenes 219

IX. Thiophene Compounds Containing Nitrogen in the Side Chain 241

X. Hydroxythiophenes, Thienylalkanols, Alkoxythiophenes, and Thienyl-alkyl Ethers 287

XI. Aldo and Keto Derivatives of Thiophene 307

XII. Carboxy Derivatives of Thiophene 363

XIII. Sulfur Derivatives of Thiophene 417

XIV. Metal and Miscellaneous Metalloid Derivatives of Thiophene 439

XV. Synthesis and Properties of Di- and Polythienyls and Arylthiophenes 459

XVI. Selenophene, Tetrahydroselenophene, Tellurophene, and Tetrahydrotellurophene 479