The Aptamer Handbook: Functional Oligonucleotides and Their Applications

HISTORY AND THEORETICAL BACKGROUND
In vitro selection of functional oligonucleotides and the origins of biochemical activity (J. M. Carothers and J. Szostak)
Mathematical models on RNA evolution, simulations in silico, and concepts for in vitro selection (P. Schuster)
Fitness landscapes, error thresholds, and cofactors in aptamer evolution (A. Kun, M. Maurel, M. Santos, E. Szathmary)

IN VITRO SELECTION OF TARGET BINDING OLIGONUCLEOTIDES
Aptamers to small molecules (H. Fickert, I. Fransson, U. Hahn)
Aptamers to antibiotics (C. Lorenz, R. Schroeder)
Aptamers to proteins (S. Nimjee, C. Rusconi, B. Sullenger)
Aptamers to nucleic acid structures (J. Toulme, F. Darfeuille, C. Di Primo, E. Dausse)
Natural aptamers - riboswitches (R. Welz, A. Roth, R. Breaker)

IN VITRO SELECTION OF SHORT CATALYTICALLY ACTIVE OLIGONUCLEOTIDES
Catalytically active RNA molecules: tools in organic chemistry (B. Weigand, A. Zerressen, J. Schlatterer, M. Helm, A. Jaschke)
Deoxyribozymes: Catalytically active DNA molecules (K. Schlosser, S. McManus, Y. Li)

APPLICATIONS AND OUTLOOK
In vivo and in vitro target validation with nucleic acid aptamers as pharmacological probes (S. Pendergast, D. Epstein)
Intramers for protein function analysis and drug discovery (M. Famulok, G. Mayer)
Aptazymes: allosteric ribozymes and deoxyribozymes as biosensors (S. Knudsen, A. Ellington)
Conversion of aptamer lead structures into small molecules (A. Jenne)
Aptamers as ligands for affinity chromatography and capillary electrophoresis applications (E. Peyrin)
Aptamers for in vivo imaging (S. Borkowski, L. Dinkelborg)
Properties of therapeutic aptamers (S. Cload, T. McCauley, A. Keefe, J. Healy, C. Wilson)
Spiegelmers for therapeutic applications (D. Eulberg, F. Jarosch, S. Vonhoff, S. Klussmann)
Applications in the clinic: the anti-VEGF aptamer (T. Realini, E. Ng, A. Adamis)
Aptamers after fifteen years (L. Gold)