Skeletal Development and Remodeling in Health, Disease and Aging, Volume 1068

1. PTHrP and Skeletal Development: Henry Kronenberg.

2. Regulating Bone Growth with BMPs: Phoebe Leboy.

3. BMP and BMP Inhibitors in Bone: Vicki Rosen.

4. BMP Signaling and Skeletalogensis: Xu Cao.

5. Function of BMP and BMP Antagonist in Adult Bone: Etsuko Abe.

6. Dysregulation of the BMP4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva: Frederick Kaplan.

7. Hypoxia, HIF-1Ą and VHL in Chondrogenesis: Ernestina Schipani.

8. Cellular and Molecular Mechanisms of Synovial Joint and Articular Cartilage Formation: Maurizio Pacifici.

9. Multiple Roles of Hoxc8 in Skeletal Development: Aster Juan et al.

Part II: Skeletal Remodeling:.

10. Osteoclasts and Integrins: Steven Teitelbaum.

11. Regulation of Osteoclast Differentiation: David Roodman.

12. Signaling in Osteoclast and their Precursors: Patrick Ross.

13. Canonical Wnt Signaling in Osteoblasts is Required for Osteoclast Differentiation: Gerard Karsenty.

14. Inhibition of ATF4 Transcriptional Activity by TIAT/ƒ×-Taxilin Modulates Bone Mass: Rene St. Arnaud.

15. Paget's Disease of Bone and Genetic Disorders of RANK/OPG/RANK/NF-ƒÛB signaling: Michael Whyte.

16. The Regulation of Cathepsin K Gene Expression: Bruce Troen.

17. Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts: Alberta Zallone.

18. Molecular Mechanism of the Life and Death of the Osteoclast: Sakae Tanaka.

19. Understanding Parathyroid Hormone Action: Nicola Partridge.

20. New Insights Into the Mechanisms Involved in The Pleiotropic Actions of 1,25dihydroxyvitamin D3: Sylvia Christakos.

21. Mechanisms of Vitamin D Receptor Action: Marie Demay.

22. Role of Connexin 43 in Osteoblast Response to Physical Load: Roberto Civitelli.

23. Interactive Effect of Interleukin-6 and Prostaglandin E2 on Osteoclastogenesis via the OPG/RANK-L/RANK System: Xin-Hua Liu.

24. Does TNF Have Anti-Osteoclastogenic Actions?: Jameel Iqbal.

25. Eosinophil Chemotactic Factor-L (ECF-L) Enhances Osteoclast Formation by Increasing ICAM-1 Expression: Garcia Palacios and David Roodman.

Part III: Mechanisms Of Bone Loss:.

26. Bone Cell Precursors and the Pathophysiology of Bone Loss: Harry Blair and Jill Carrington.

27. Autosomal Dominant Pseudohypoparathyroidism Type 1b is Caused by Different Microdeletions Within or Upstream of the GNAS Locus: Harold Jueppner.

28. Estrogen Regulation of Immune Cells Bone Interactions: Roberto Pacifici.

29. Autoimmunity and Bone: Edward Schwarz.

30. Non-Steroid Immune Modulators and Bone Disease: Solomon Epstein.

31. Pathogenesis of Osteopenia/Osteoporosis Induced by Highly Active Anti-Retroviral Therapy for AIDS: Jay McDonald.

32. Pituitary Hormones and Bone Loss: Mone Zaidi.

33. Bone Destruction in Multiple Myeloma: Toshio Matsumoto.

34. Osteogenic Regulation of Vascular Calcification: Dwight Towler.

35. The OPG/TRAIL Complex in an In Vitro Osteoclastogenesis Model Dervied From Human Multiple Myeloma Bone Disease: Maria Grano et al.

36. Restoration of Bone Mass in hpg Mouse by Preoptic Area Grafting: Gopalan Rajendren.

37. IL-7 Drives T Cell-Medicated Bone Loss Following Ovariectomy: Michaela Robbie-Ryan and M. Neale Weitzmann.

Part IV: Restoring Skeletal Strength:.

38. Stem Cells and Tissue Engineering: Past, Present and Future: Julia Polak.

39. Bisphosphonates: From Bench to Bedside: Graham Russell.

40. Novel Targets and Therapeutics for Bone Loss: Ronald N. Margolis and Sunil J. Wimalawansa.

41. Advanced Imaging Assessment of Bone Quality: Harry Genant.

42. Bone Strength: Current Concepts: Charles Turner.

43. Anti-Catabolic Therapeutic Target in Bone Disease: Brendan Boyce.

44. Mechanisms Involved in Skeleton Anabolic Therapies: Jack Martin.

45. Misconceptions About Calcimimetics: Edward Nemeth.

46. Osteoblastic Activation in the Hematopoetic Stem Cell Niche: Laura Calvi.

47. Circulating Cells with Osteogenic Potential: Sundeep Khosla.

48. The Pericellular Matrix as a Transducer of Biomechanical Signals in Auricular Cartilage: Farshid Guilak.

49. Clinical Biophysics: The Promotion of Skeletal Repair by Physical Force: Roy Aaron.

50. COX-2 has a Critical Role During Incorporation of Structural Bone Allografts: Regis O'Keefe.

51. The Effect of Anti-TNF Therapy on Spinal Bone Mineral Density in Crohn¡¦s Disease: Michael Pazianas.

52. Bone Remodeling in Health and Disease: Lessons from Mathematical Modeling: Svetlana V Komarova.

53. Modeling of Serum C-Telopeptide Levels with Daily and Monthly Oral Ibandronate: Mone Zaidi.

54. NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis: Majd Zayzafoon.

55. Mechanical Loading Differentially Regulates Membrane Bound and Soluble RANKL Availability in MC3T3-E1 Cells: Dae Won Kim and Francis Y. Lee.

Index of Contributors