Neuroprotective Agents: Seventh International Conference, Volume 1053ISBN: 978-1-57331-579-1
Paperback
520 pages
September 2005, Wiley-Blackwell
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The wide range of contributions to this volume, from a detailed
paper on the use of gene therapy in combination with hypothermia
for the treatment of cerebral ischemia to a comprehensive poster
describing the role of anesthetic agents in neurotoxicity during
development and senescence, illustrate the scientific scope
presented.
Contributions from clinical and basic science researchers from
many disciplines address various approaches to providing
neuroprotection. The clinical focus is on the complexity of
neuroprotection, the need for understanding the time-course effects
of hypoxia/ischemia, and the need for combinational and time-course
applications of multiple therapies. New technologies are introduced
for describing both the insult and the treatment necessary for
neuroprotection, including gene expression assays (genomics) and
gene therapy.
Several chapters are devoted to the examination of the
predictive value of models for outcome measures in clinical
ischemic stroke neuroprotective trials. The need to move from in
vitro models to more predictive in vivo approaches with the use of
pharmacokinetics is addressed. Other chapters emphasize the role of
endogenous agents such as nitric oxide, melatonin, L-carnitine, and
estrogens in acute and chronic neural injury and therapy.
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