Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072

Where Do We Go From Here?: S.R. Targan.

Part I: Genetics of Inflammatory Bowel Disease –NOD/CARD Proteins: Diagnostic and Therapeutic Consequences?:.

1. Microbial Signaling Through NOD Proteins: D. Philpott.

2. NOD2/CARD Mutations in Crohn’s Disease: J.P. Hugot.

3. Functional Relevance of NOD2 On Cellular Signalling in Crohn's Disease: G. Nunez.

4. Do Genetic Mutations Provide New Insights for Therapy?: J. Cho.

Part II: Immunologic Abnormalities in IBD – What Can We Learn From Animal Models?:.

5. Role of TGFβ in Mucosal Inflammation: W. Strober.

6. TNF/TNFR-Pathways in Chronic Inflammation: G. Kollias.

7. Lessons From Enteric Infections: L. Eckmann.

8. New Insights From Studies of Regulatory T Cell Populations: A. O'Garra.

9. the Commensal Microbial Flora: Relevance for Intestinal Inflammation: C.O. Elson.

Part III: Immunologic Disturbances in Human IBD – Defining and Manipulating the Key Pathways:.

10. Chemokines and Cell Trafficking Within the Inflamed Mucosa -- Inhibition of Chemokine Receptors or Ligands as a Potential Approach for Treatment?: I.R. Williams.

11. Life and Death – the Role of Apoptosis: T. Kucharzik.

12. Cytokines – Who Are the Key Plays and the Role for Cytokine Treatment: R.S. Blumberg.

13. Novel Signal Transduction Pathways – Relevance for Future Therapies?: M.F. Neurath.

14. NF-Kappa-B Signaling –the Pros and Cons of Altering NF-κB as a Therapeutic Approach: M. Karin.

15. Intracellular Targets: a Role for Inhibition of MAP-Kinases in Therapy?: S.J. Deventer.

16. Leucocyte Adhesion Molecules – Are They Relevant as Target for IBD Treatment?: D.B. Binion.

Part IV: Intestinal Epithelial Cells in IBD - An Active Barrier?:.

17. Tight Junction Function and the Modulation of Paracellular Permeability During IBD: a. Nusrat.

18. Epithelial Transport Under Inflammatory Conditions – Can It Be Regulated?: M.C. Berin.

19. Imbalance of Epithelial Electrolyte Homeostasis – Role in the Pathophysiology of IBD: U. Seidler.

20. Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD – Potential Targets for Inhibiting Neutrophil Trafficking: C.A. Parkos.

Part V: GALT – Relevant for Regulation of Inflammation?:.

21. Collaboration of Epithelial Cells With Organized Lymphoid Tissue: M.J. Kraehenbuhl.

22. Role of Lymphotoxins in the Development of PP and MLN – Relevance to Intestinal Inflammation and Treatment: T.W. Spahn.

23. Trafficking and Function of Mucosal Dendritic Cells: A. Iwasaki.

24. Intraepithelial T-Cells – Implication for Intestinal Inflammation: M. Kronenberg.

Part VI: Relevance of Microbial Factors – Additive Or Causative for IBD?:.

25. Microbial – Epithelial Cell Crosstalk During Inflammation: The Host Response: M. Kagnoff.

26. Role of Toll-Like Receptors in Orchestrating the Innate Immune Response – Potential Targets for Treatment?: D. Podolsky.

27. Host-Bacterial Interactions in the Gut: Signalling by Commensal Flora: J. Gordon.

28. Immunostimulatory DNA- Potential Therapeutics for Treatment of Enteric Inflammatory Disease?: E. Raz.

29. Probiotics – Their Role in Controlling Intestinal Inflammation?: J.F. Colombel.

30. Inflammatory Bowel Disease – Pandora's Box, Present and Future: J. Schölmerich.

Index of Contributors