Fluorine in Medicinal Chemistry and Chemical BiologyISBN: 978-1-4051-6720-8
Hardcover
640 pages
April 2009, Wiley-Blackwell
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The extraordinary potential of fluorine-containing molecules in
medicinal chemistry and chemical biology has been recognized by
researchers outside of the traditional fluorine chemistry field,
and thus a new wave of fluorine chemistry is rapidly expanding its
biomedical frontiers. With several of the best selling drugs in the
world crucially containing fluorine atoms, the incorporation of
fluorine to drug leads has become an essential practice in
biomedical research, especially for drug design and discovery as
well as development.
Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include:
- Discovery and development of fluorine containing drugs and drug candidates.
- New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates.
- Structural and chemical biology of fluorinated amino acids and peptides.
- Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis.
- Applications of 19F NMR spectroscopy in biomedical research.
An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action.
Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.