Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach

Foreword.

Part I: Gastroesophageal Cancer.

1 Epidemiology of Gastroesophageal Cancer.

2 Factors involved in Carcinogenesis and Prevention.

3 Molecular Biology of Gastroesophageal Cancers: the Role of Mutational Analysis in Prognosis.

4 Esophageal Adenocarcinoma.

Diagnosis:.

Endoscopic diagnosis of Barrett’s esophagus.

The histologic diagnosis of Barrett’s esophagus.

Staging of esophageal cancer.

Treatment.

Overview.

Surgical management of esophageal carcinoma.

Chemotherapy for metastatic cancer of the esophagus, gastroesophageal junction, and stomach.

Concurrent radiochemotherapy for esophageal cancer.

Ablation, novel agents, and endoscopic therapy for esophageal dysplasia and carcinoma.

Prognosis and follow-up.

5 Squamous Cancer of the Esophagus.

Diagnosis.

History and etiology.

Clinical.

Histopathology and staging.

Imaging and clinical staging.

Treatment.

Overview.

Surgery.

Chemotherapy.

Radiotherapy.

Ablation of early cancer.

Palliation and endoscopic therapy.

Novel agents.

Prognosis and follow-up.

6 Diffuse Gastric Cancer.

Diagnosis.

History.

Clinical.

Histopathology and molecular pathology.

Imaging and staging of gastric cancer.

Treatment.

Overview.

Surgery.

Chemotherapy.

Radiotherapy.

Novel agents.

Prognosis and follow-up.

7 Intestinal Gastric Cancer.

Diagnosis: history, clinical and histopathology.

Imaging and staging.

Treatment.

Prognosis and follow-up.

8 Small Bowel Tumors.

Diagnosis.

Epidemiology.

Endoscopy in the diagnosis of small bowel tumors.

Molecular biology of small bowel tumors.

Imaging and staging.

Treatment.

Surgery.

Other treatments.

9 Sarcoma and Gastrointestinal Stromal Tumors.

Introduction.

Pathology, prognosis and genetics of gastrointestinal stromal tumors (GISTs).

Imaging and staging of gastrointestinal stromal tumors.

Treatment.

10 Rare Tumors of the Abdomen.

Smooth muscle and pericytic tumors.

Vascular tumors.

Adipose tissue tumors of Pathology.

Neurogenic tumors.

Myofibroblastic and fi brous tumors.

Mesothelial tumors.

Gastric lymphomas.

Rare miscellaneous tumors and tumor-like lesions.

Part II: Colorectal Cancer.

11 Epidemiology and Prevention of Colorectal Cancer.

12 The Molecular Pathology of Sporadic and Hereditary Colorectal Cancer.

13 Screening for Colorectal Cancer.

14 Cancer of the Colon and Rectum.

Diagnosis.

Clinical presentation.

Histopathology.

Treatment.

Overview of therapy modalities.

Surgery.

Chemotherapy.

Radiotherapy for rectal cancer.

Surgery for liver metastases.

Ablative treatments.

Novel therapies.

Stomas.

Answers to case scenerios.

15 Rare Cancers.

Gastrointestinal carcinoids.

Anorectal melanoma.

Cancer of the anal canal.

Diffuse malignant peritoneal mesothelioma.

Part III: Hepatobiliary Cancer.

16 Epidemiology of Hepatocellular Carcinoma.

17 Factors involved in Carcinogenesis and Prevention in Hepatobiliary Cancer.

18 Molecular Biology of Hepatobiliary Cancer.

19 Primary Liver Cancer.

Diagnosis.

History and clinical.

Histopathology.

Imaging and staging.

Treatment.

Overview.

Surgery.

Ablation.

Radiotherapy.

Chemotherapy.

Novel agents.

Prognosis and follow-up.

20 Metastatic Liver Cancer.

Treatment.

Overview.

Surgical therapy for hepatic colorectal metastases.

Systemic chemotherapy.

Ablative Therapy.

Radiation therapy.

21 Primary Pancreatic Adenocarcinoma.

Diagnosis.

Epidemiology, history and clinical findings.

Histopathology.

CT imaging in pancreatic cancer.

Treatment.

Overview.

Surgery.

Chemotherapy.

Radiotherapy.

Novel agents.

Prognosis and follow-up.

22 Cholangiocarcinoma.

Diagnosis.

Overview.

History.

Clinical.

Histopathology.

Imaging and Staging.

Treatment.

Overview.

Surgery.

Chemotherapy.

Role of radiation therapy.

Ablation.

Prognosis and follow-up.

23 Neuroendocrine Tumors.

History and histopathology.

Diagnosis, staging, prognosis and follow-up.

Gastric neuroendocrine tumors.

Gastrinoma.

Insulinoma.

Non-functioning endocrine tumors of the pancreas.

Rare functioning pancreatic endocrine tumors.

Midgut and appendiceal tumors.

Neuroendocrine tumors of the colon and rectum.

Imaging of gastroenteropancreatic neuroendocrine tumors.

Treatment.

Overview.

Surgery: pancreatic tumors.

Surgery: midgut tumors.

Surgery: liver metastases.

Ablative therapy.

Radiolabeled somatostatin analogs.

Biotherapy and chemotherapy.

Novel agents.

24 Rare Tumors of the Liver.

25 Cystic Neoplasms of the Pancreas.

Diagnosis and imaging.

Treatment recommendations.

Endoscopic assessment and treatment.

Index