Acquired Long QT Syndrome

Preface vi

1 Introduction 1

2 Mechanisms of acquired QT prolongation and torsades de pointes 8

3 Measurement of the QT interval and repolarization assessment 24

4 Introduction to drug-induced long QT syndrome 60

5 Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs 69

6 Risk of QT prolongation and torsades de pointes with antihistamines 87

7 Risk of QT prolongation and torsades de pointes with psychotropic drugs 102

8 Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs 121

9 Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs 140

10 Acquired long QT syndrome secondary to cardiac conditions 163

11 Acquired long QT syndrome secondary to noncardiac conditions 171

12 Perspective on drug-induced repolarization changes 182

Index 191