Advances in Enzymology and Related Areas of Molecular Biology, Volume 78

Preface ix

Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin

Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile

Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian

Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161
Soo-Youl Kim

Transglutaminase 2 At the Crossroads between Cell Death and Survival 197
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo

Tissue Transglutaminase and Its Role in Human Cancer Progression 247
Bo Li, Richard A. Cerione, and Marc Antonyak

Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus

Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347
Zoltan Nemes

Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti

Irreversible Inhibitors of Tissue Transglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin

Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449
Marıa A. Pajares and George D. Markham

Index 523