Organic Syntheses, Volume 87ISBN: 978-1-118-00514-9
Hardcover
456 pages
January 2011
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Metal-Free One-Pot Oxidative Amination of Aromatic Aldehydes:
Conversion of Benzaldehyde to N-Benzoyl Pyrrolidine 1
Kekeli Ekoue-Kovi and Christian Wolf
A Practical and Scalable Synthesis of N-Halo Compounds:
2-Chloro-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline 8
Yong-Li Zhong and Paul G. Bulger
Regioselective C-4 Bromination of Oxazoles:
4-Bromo-5-(Thiophen-2-YL) Oxazole 16
Bryan Li, Richard A. Buzon, and Zhijun Zhang
Synthesis of Spiroborate Esters from 1,2-Aminoalcohols, Ethylene
Glycol and Triisopropyl Borate: Preparation of
(S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine
26
Viatcheslav Stepanenko, Kun Huang and Margarita
Ortiz-Marciales
Catalytic Enantioselective Borane Reduction of Benzyl Oximes:
Preparation of (S)-1-Pyridin-3-YL-Ethylamine BIS Hydrochloride
36
Kun Huang and Margarita Ortiz-Marciales
Stereoselective Synthesis of 3-Arylacrylates by Copper-Catalyzed
Syn Hydroarylation 53
Naohiro Kirai and Yoshihiko Yamamoto
Preparation of
(S)-3,3’-BIS-Morpholinomethyl-5,5’,6,6’,7,7’,8,8’-Octahydro-1,1’-BI-2-Naphthol
59
Mark Turlington and Lin Pu
Catalytic Asymmetric Addition of an In-Situ Prepared Arylzinc to
Cyclohexanecarboxaldehyde:
(R)-(+)-α-Cyclohexyl-3-Methoxy-Benzenemethanol 68
Albert M. DeBerardinis, Mark Turlington, and Lin Pu
Microwave-Assisted Synthesis of 1,3-Dimesitylimidazolinium
Chloride 77
Morgan Hans and Lionel Delaude
Synthesis of (3-Chlorobutyl)Benzene by the Cobalt-Catalyzed
Hydrochlorination of 4-Phenyl-1-Butene 88
Boris Gaspar, Jerome Waser, and Erick M. Carreira
Synthesis of Substituted Indazoles via (3+2) Cycloaddition of
Benzyne and Diazo Compounds 95
Feng Shi and Richard C. Larock
Palladium-Catalyzed Cross-Coupling Using an Air-Stable
Trimethylaluminum Source. Preparation of Ethyl 4-Methylbenzoate
104
Andrej Vinogradov and Simon Woodward
Synthesis of Dimethyl 2-Phenycyclopropane-1,1-Dicarboxylate
Using an Iodonium Ylide Derived from Dimethyl Malonate 115
Sébastien R. Goudreau, David Marcoux and Andre B.
Charette
New, Convenient Route for Trifluoromethylation of Steroidal
Molecules 126
Xiang-Shu Fei, Wei-Sheng Tian, Kai Ding, Yun Wang and Qing-Yun
Chen
Preparation of Ethyl 1-Benzyl-4-Fluoropiperidine-4-Carboxylate
137
Jianshe Kong, Tao Meng, Pauline Ting, and Jesse Wong
Lithium Amides as Homochiral Ammonia Equivalents for Conjugate
Additions to α,ß-Unsaturated Esters: Asymmetric Synthesis
of (S)-ß-Leucine 143
Stephen G. Davies, Ai M. Fletcher, and Paul M. Roberts
Cyclohexene Imine (7-Aza-Bicyclo[4.1.0]Heptane) 161
Iain D. G. Watson, Nicholas Afagh and Andrei K. Yudin
Preparation of (E)-(2-Iodovinyl)Benzene From Benzyl Bromide and
Diiodomethane 170
James A. Bull, James J. Mousseau and André B.
Charette
Synthesis of Tetraorganosilanes:
(Chloromethyl)Dimethylphenylsilane 178
Submitted by Kei Murakami, Hideki Yorimitsu, and Koichiro
Oshima
A General Method for Copper-Catalyzed Arylation of Acidic Arene
C-H Bonds. Preparation of 2-Chloro-5-(3-Methylphenyl)-Thiophene
184
Joseph Alvarado, Hien-Quang Do, and Olafs Daugulis
1,3,5-Triacetylbenzene 192
Peter J. Alaimo, Amanda-Lynn Marshall, David M. Andrews and
Joseph M. Langenhan
Organocatalytic α-Methylenation of Aldehydes: Preparation
of 3,7-Dimethyl-2-Methylene-6-Octenal 201
Meryem Benohoud, Anniina Erkkilä, and Petri M.
Pihko
Ruthenium-Catalyzed Arylation of Ortho C-H Bond in an Aromatic
with an Arylboronate: 8-Phenyl-1-Tetralone 209
Kentaroh Kitazawa, Takuya Kochi, and Fumitoshi Kakiuchi
Amide Formation by Decarboxylative Condensation of
Hydroxylamines and α-Ketoacids: N-[(1S)-1
Phenylethyl]-Benzeneacetamide 218
Lei Ju and Jeffrey W. Bode
One-Pot Diazotization and Heck Reaction of Methyl Anthranilate:
2-(3-Oxopropyl) Benzoic Acid Methyl Ester 226
Florencio Zaragoza
Synthesis of Ynamides by Copper-Mediated Coupling of
1,1-Dibromo-1-Alkenes with Nitrogen Nucleophiles. Preparation of
4-Methyl-N-(2-Phenylethynyl)-N-(Phenylmethyl)Benzenesulfonamide
231
Alexis Coste, François Couty and Gwilherm Evano
Direct Fluorination of the Carbonyl Group of Benzophenones Using
Deoxo-Fluor®: Preparation of BIS(4-Fluorophenyl)
Difluoromethane 245
Ying Chang, Hyelee Lee, Chulsung Bae
Preparation and [2+2] Cycloaddition of
1-Triisopropylsiloxy-1-Hexyne with Methyl Crotonate:
3-Butyl-4-Methyl-2-Triisopropylsiloxy-Cyclobut-2-Enecarboxylic Acid
Methyl Ester 253
Valeriy Shubinets, Michael P. Schramm, and Sergey A.
Kozmin
Pd(0)-Catalyzed Asymmetric Allylic and Homoallylic Diamination
of 4-Phenyl-1-Butene with DI-Tert-Butyldiaziridinone 263
Baoguo Zhao, Haifeng Du, Renzhong Fu, and Yian Shi
Synthesis of Enamides from Ketones: Preparation of
N-(3,4-Dihydronaphthalene-1-YL)Acetamide 275
Hang Zhao, Charles P. Vandenbossche, Stefan G. Koenig, Surendra
P. Singh, and Roger P. Bakale
Safe and Scalable Preparation of Barluenga’s Reagent
288
Justin M. Chalker, Amber L. Thompson, and Benjamin G.
Davis
Palladium-Catalyzed Alkyl-Alkyl Suzuki Cross-Couplings of
Primary Alkyl Bromides at Room Temperature:
(13-Chlorotridecyloxy)Triethylsilane 299
Sha Lou and Gregory C. Fu
Synthesis of Chiral Pyridine Bis(Oxazoline) Ligands for
Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary
allylic Chlorides with
Alkylzincs:2,6-BIS[(4R)-4,5-Dihydro-4-(2-Phenylethyl)-2-Oxazolyl]-Pyridine
310
Sha Lou and Gregory C. Fu
Nickel-Catalyzed Asymetric Negishi Cross-Couplings of Racemic
Secondary Allylic Chlorides with Alkylzincs: (S,E)-Ethyl
6-(1,3-Dioxolan-2-YL)-4-Methylhex-2-Enoate 317
Sha Lou and Gregory C. Fu
Nickel-Catalyzed Enantioselective Negishi Cross-Couplings of
Racemic Secondary a-Bromo Amides with Alkylzinc Reagents:
(s)-N-Benzyl-7-Cyano-2-Ethyl-N-Phenylheptanamide 330
Sha Lou and Gregory C. Fu
One-Pot Synthesis of 5H-Indazolo-[3,2-b] Benzo[d]-1,3-Oxazine:
Two Efficient Preparative Methods 339
Danielle M. Solano, Jeffrey D. Butler, Makhluf J. Haddadin and
Mark J. Kurth
Preparation of Chiral and Achiral Triazolium Salts: Carbene
Precursors with Demonstrated Synthesis Utility 350
Harit U. Vora, Stephen P. Lathrop, Nathan T. Reynolds, Mark S.
kerr, Javier Read de Alaniz, and Tomislav Rovis
Synthesis of A N-Mesityl Substituted Aminoindanol-Derived
Triazolium Salt 362
Justin R. Struble and Jeffrey W. Bode
Preparation of O-Allyl-N-(9-Anthracenyl-Methyl)-Cinchonidium
Bromide as a Phase Transfer Catalyst 377
E. J. Corey and Mark C. Noe