Enzyme Systems that Metabolise Drugs and Other XenobioticsISBN: 978-0-471-89466-7
Hardcover
588 pages
December 2001
This is a Print-on-Demand title. It will be printed specifically to fill your order. Please allow an additional 10-15 days delivery time. The book is not returnable.
|
This definitive reference work describes in detail the enzyme
systems that participate in the metabolism of xenobiotics,
particularly medicinal drugs. Each chapter focuses on a specific
enzyme system, emphasising its role in the activation and
detoxication of chemicals. Aspects discussed critically
include:
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior exposure to other chemicals
* age-dependent expression
* pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior exposure to other chemicals
* age-dependent expression
* pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.