Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development

Preface.

Acknowledgments.

Contributors.

Abbreviations. 

PART I: CELLULAR FUNCTIONS OF GSK-3.

1. Glycogen Synthase Kinase-3 - an Introductory Synopsis  .

2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective.

3. Role of GSK3/Shaggy in neuronal cell biology.

4. The Crystal Structures of Glycogen Synthase Kinase 3.

5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3.

PART II: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY.

6. GSK-3, a Key Player in Alzheimer’s Disease.

7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments.

8. GSK3 and Stem Cells.

9. Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection.

10. Protein Kinase Inhibitors. Assay Development.

11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies.

PART III: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL.

12. Lithium, the Seminal GSK3 Inhibitor.

13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418.

14. TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors.

15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors.

16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors.

Index.