Mass Spectrometry in Drug Metabolism and Pharmacokinetics

About the Editor ix

Contributors xi

1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1
Dil M. Ramanathan and Richard M. LeLacheur

2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87
Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen

3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123
Elliott B. Jones

4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening 159
Jose M. Castro-Perez

5. Changing Role of FTMS in Drug Metabolism 191
Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders

6. High-Resolution LC–MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223
Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray

7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253
Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and Don Walker

8. Online Electrochemical–LC–MS Techniques for Profiling and Characterizing Metabolites and Degradants 275
Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth

9. LC–MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine 295
Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton

10. Turbulent-Flow LC–MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311
Joseph L. Herman and Joseph M. Di Bussolo

11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341
Jason S. Gobey, John Janiszewski, and Mark J. Cole

12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359
Yunsheng Hsieh and Walter A. Korfmacher

Index 383