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The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity

Jamie A. Goode (Editor), Derek J. Chadwick (Editor)
ISBN: 978-0-471-49959-6
Hardcover
312 pages
November 2001
List Price: US $235.00
Government Price: US $135.63
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The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity (0471499595) cover image

Introduction (Robert J Gillies).

Frontiers in the Measurement of Cell and Tissue pH (Robert J Gillies and Ronald M Lynch).

The Physiological Environment in Cancer Vascularization, Invasion and Metastasis (Zaver M Bhujwalla et al).

Why are Cancers Acidic? A Carrier-Mediated Diffusion Model for H+ Transport in the Interstitial Fluid (J R Griffiths et al).

pH and Therapy of Human Cancers (Jeffrey L Evelhoch).

Mathematical Models of Tumour Invasion Mediated by Transformation-Induced Alteration of Microenvironmental pH (Robert A Gatenby and Edward T Gawlinski).

pH Regulation of Renal Gene Expression (Norman P Curthoys et al)).

Genetic Determinants that influence Hypoxia-Induced Apoptosis (Rodolfo M Alarcon et al).

Genomic Instability in Cancer (Sara Rockwell et al).

pH, Hypoxia and Metastasis (R P Hill et al).

Modelling Tumour Acidity and Invasion (Steven D Webb et al).

pH, Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth (Jacques Pouyssé gur et al).

pH and Chemotherapy (Natarajan Raghunand).

The HIF Pathway: Implications for Patterns of Gene Expression in Cancer (Charles C Wykoff et al).

pH and Multidrug Resistance (Paul D Roepe).

'The Metabolism of Tumours' 70 Years Later (Gregg L Semenza et al).

The Multiple Mechanisms of Multidrug Resistance and Cellular pH (Sanford Simon).

Summing Up (Robert J Gillies).

Index of Contributors.

Subject Index.

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