Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate LibrariesISBN: 978-0-471-37828-0
Hardcover
320 pages
August 2001
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Solid-phase synthesis of carbohydrates presents unique challenges
to synthetic chemists and currently represents one of the hottest
areas of research in bioorganic chemistry. Solid Support
Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
addresses the exciting expectation that solid-phase assembly of
oligosaccharides will have a fundamental impact on the field of
glycobiology. This publication details the methodologies currently
investigated for the attachment of carbohydrates to beads,
synthesis including coupling strategies, and removal of the product
from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
- Specific oligosaccharide structures used in signal transduction
processes
- Preparation and screening of glycopeptide libraries
- Solid-phase carbohydrate synthesis