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Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities

ISBN: 978-0-471-24743-2
Hardcover
421 pages
January 1999
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MOLECULAR BIOLOGY AND BIOCHEMISTRY.

Purification and Cloning of Nicotinic Acetylcholine Receptors (J.Lindstrom).

Transcriptional Regulation of Neuronal Nicotinic Receptor SubunitGenes (D. Fornasari, et al.).

Molecular Composition and Biophysical Characteristics of NicotinicReceptors (J. Ramirez-Latorre, et al.).

Desensitization and the Regulation of Neuronal Nicotinic Receptors(M. Marks).

Cell Lines as Models for Studies of Nicotinic AcetylcholineReceptors (R. Lukas).

Stable Expression of Human Neuronal Nicotinic Receptors (B.Buisson, et al.).

PHYSIOLOGICAL ROLES OF NICOTINIC RECEPTORS.

Functional Anatomy of Nicotinic Acetylcholine Receptors inMammalian Brain (P. Clarke).

Nicotinic Receptor Modulation of Neurotransmitter Release (S.Kaiser & S. Wonnacott).

Functional Diversity of Nicotinic Acetylcholine Receptors in theMammalian Central Nervous System: Physiological Relevance (E.Pereira, et al.).

Diverse Functions of Neuronal Nicotinic Receptors Determined bySubcellular Location (D. Berg, et al.).

Immunosuppressive and Anti-inflammatory Properties of Nicotine (M.Sopori).

PHARMACOKINETICS OF NICOTINE-LIKE ALKALOIDS.

Pharmacokinetics and Metabolism of Nicotine and Related Alkaloids(N. Benowitz & P. Jacob).

Nicotine and Related Compounds as PET and SPECT Ligands (V.Villemagne, et al).

MEDICINAL CHEMISTRY.

Natural Products as a Source of Nicotinic Acetylcholine ReceptorModulators and Leads for Drug Discovery (M. Holladay, etal.).

Nicotinic Cholinergic Receptor Pharmacophores (R. Glennon & M.Dukat).

CURRENT AND POTENTIAL THERAPEUTIC APPLICATIONS.

Neuronal Nicotinic Receptor Channel Dysfunction in a Human EpilepsySyndrome (D. Bertrand & S. Berkovic).

The Role of Nicotine and Nicotinic Receptors in Psychopathology (S.Leonard, et al.).

Nicotine and Non-Nicotine Formulations for Smoking Cessation (S.Leischow & G. Cook).

Preclinical Evidence on the Neuroprotective Effects of NicotinicLigands (D. Donnelly-Roberts & J. Brioni).

Transdermal Nicotine Treatment of Attention Deficit HyperactivityDisorder (E. Levin, et al.).

Neuronal Nicotinic Receptors: New Targets in the Treatment of Pain(C. Flores & K. Hargreaves).

Subtype-Selective nAChR Agonists for the Treatment of NeurologicalDisorders: SIB-1508Y and SIB-1553A (F. Menzaghi, et al.).

Nicotinic Acetylcholine Receptor-Targeted Compounds: A Summary ofthe Development Pipeline and Therapeutic Potential (M. Decker &S. Arneric).

Index.

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