Human Drug Metabolism: An Introduction, 2nd EditionISBN: 978-0-470-74216-7
Paperback
360 pages
May 2010
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Completely revised and updated throughout with new chapter
on drug metabolism and disease states with the Clinical
Relevance Section revised to include current clinical status of
CYP2D6/CYP2C9 genotyping (cost problems, lack of physician
knowledge, uncertainty as to how the information can be used) as
well as cost/benefit.
· More emphasis on genotyping value for warfarin and a more balanced clinical appraisal of value of genotyping for specific drugs (e.g. perhexiline, nortryptyline.
- New material includes; more examples of induction with newer anticonvulsants, OTC herbal remedies with expanded coverage of the impact on protease inhibitors
- New section on Butyrylcholinesterase and the neuromuscular blockers (mivacurium etc) and new material on dihydropyrimidine dehydrogenase/5-FU and recent toxicity studies.