The Pulmonary Endothelium: Function in Health and Disease

List of Contributors xi

Introduction xvii
Sharon Rounds and Norbert Voelkel

Section I: Normal Pulmonary Endothelium. Structure, Function, Cell Biology 1

1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 3
Margaret A. Schwarz and Ondine B. Cleaver

2: Anatomy of the Pulmonary Endothelium 25
Radu V. Stan

3: Cadherins and Connexins in Pulmonary Endothelial Function 33
Kaushik Parthasarathi and Sadiqa K. Quadri

4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 51
Katie L. Grinnell and Elizabeth O. Harrington

5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 73
Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta

6: Pulmonary Endothelium and Nitric Oxide 89
Yunchao Su and Edward R. Block

7: Pulmonary Endothelial Cell Surface Metabolic Functions 105
Usamah S. Kayyali and Barry L. Fanburg

8: Cell Biology of Lung Endothelial Permeability 113
Guochang Hu and Richard D. Minshall

9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 129
Donna L. Cioffi, Songwei Wu and Troy Stevens

10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 143
Rosana Souza Rodrigues and Guy A. Zimmerman

11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 167
Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid

12: Pulmonary Endothelium and Vasomotor Control 185
Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta

13: Pulmonary Endothelial Progenitor Cells 203
Bernard Thébaud and Mervin C. Yoder

14: Bronchial Vasculature: The Other Pulmonary Circulation 217
Elizabeth Wagner

15: Mapping Protein Expression on Pulmonary Vascular Endothelium 229
Kerri A. Massey and Jan E. Schnitzer

Section II: Mechanisms and Consequences of Pulmonary Endothelial Cell Injury 241

16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 243
Qing Lu and Sharon Rounds

17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 261
Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher

18: Hypoxia and the Pulmonary Endothelium 287
Matthew Jankowich, Gaurav Choudhary and Sharon Rounds

19: Viral Infection and Pulmonary Endothelial Cells 303
Norbert F. Voelkel

20: Effects of Pressure and Flow on the Pulmonary Endothelium 309
Wolfgang M. Kuebler

21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 337
Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia

22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 355
Vladimir R. Muzykantov

Section III: Pulmonary Endothelium In Disease 379

23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 381
Yuansheng Gao and J. Usha Raj

24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 399
Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia

25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 417
Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel

26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease 437
Norbert F. Voelkel and Ramesh Natarajan

27: Pulmonary Endothelium and Pulmonary Hypertension 449
Rubin M. Tuder and Serpil C. Erzurum

28: Collagen Vascular Diseases and Pulmonary Endothelium 461
Pradeep R. Rai and Carlyne D. Cool

29: Pulmonary Endothelium in Thromboembolism 471
Irene M. Lang

30: Pulmonary Endothelium and Malignancies 485
Abu-Bakr Al-Mehdi

Epilogue
Norbert F. Voelkel

Index 495