Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and VaccinesISBN: 978-0-470-72338-8
Hardcover
442 pages
December 2009
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Advances in biotechnology have provided scientists with an
increasing number of biopharmaceuticals such as novel peptide and
protein drugs as well as nucleic acid based drugs for gene therapy.
However, successful delivery of these biopharmaceuticals is a major
challenge because their molecular properties lead to poor physical
and chemical stability in the body and limited membrane
permeability. Therefore researchers are developing a range of new
delivery technologies and materials to enable these new drugs to be
delivered intact to their target sites.
Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:
- challenges in delivery of biopharmaceuticals
- novel formulation approaches for peptide and protein injectables
- non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs
- immune response, adjuvants and delivery systems for vaccines
- several examples of delivery systems for different biopharmaceuticals
- a critical assessment of delivery technologies for biopharmaceuticals
Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.