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Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up

ISBN: 978-0-470-57755-4
Hardcover
376 pages
February 2011
List Price: US $159.00
Government Price: US $110.04
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Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up (047057755X) cover image
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"This book presents detailed discussions of the published process chemistry of the ten top-selling small molecule drugs in the US in 2007, information which is usually carefully protected by the current and future manufacturers." (TMCnet.com, 17 March 2011)

"[This] book contains a wealth of information, taken from the patent literature and from [the author's]decades of experience in process chemistry. Through discussions on route selection [he]introduces practical aspects of route design, including selecting non-toxic, stable and inexpensive starting materials, reactions that minimize impurity contents with optimized yields, and ease of purification. [Dr. Harrington] lays out the various approaches to successful molecules, including biocatalysis, and sorts out which routes are acceptable, creative, likely to be the manufacturing route, or merely holding space.... [This] book will be extremely valuable for the process chemist who wants to delve deeply into details critical for process optimization, and for the student new to chemical process R&D in the pharmaceutical and CRO / CMO industries."
Neal G. Anderson, Anderson's Process Solutions LLC and author of Practical Process Research & Development

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