The Septins

Authors and Affiliations vii

An introduction to the septins 1

Peter A. Hall, S. E. Hilary Russell and John R. Pringle

Section I Setting the scene 5

Chapter 1 Origins and development of the septin field 7

John R. Pringle

Chapter 2 Evolution and conserved domains of the septins 35

Michelle Momany, Fangfang Pan and Russell L. Malmberg

Section II Septins in model systems 47

Chapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49

Michael A. McMurray and Jeremy Thorner

Chapter 4 Yeast septins: a cortical organizer 101

Yves Barral

Chapter 5 Septins in four model fungal systems: diversity in form and function 125

Amy Gladfelter and Peter Sudbery

Chapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147

Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen Oegema

Section III Septins in mammals 169

Chapter 7 The genomics and regulation of the human septin

genes 171

S.E. Hilary Russell

Chapter 8 The functions of septins in mammals 187

Carol D. Froese and William S. Trimble

Chapter 9 Septin-interacting proteins in mammals 211

Brandon E. Kremer and Ian G. Macara

Chapter 10 Septin functions in the mammalian cytoskeleton 229

Elias T. Spiliotis and W. James Nelson

Chapter 11 Septins and the synapse 247

Jing Xue, Victor Anggono and Phillip J. Robinson

Chapter 12 Septins and platelets 269

Jerry Ware, Constantino Mart´ınez and Barbara Zieger

Chapter 13 Septins and apoptosis 281

Marie-Jeanne Carp and Sarit Larisch

Chapter 14 Septins and human disease 295

Peter A. Hall and Fern P. Finger

Chapter 15 Insight into septin functions from mouse models 319

Makoto Kinoshita

Section IV Envoi 337

Chapter 16 Septins: 2008 and beyond 339

Peter A. Hall, S.E. Hilary Russell and John R. Pringle

Appendix A Septin and septin-like sequences 343

Michelle Momany, Fangfang Pan and Russell L. Malmberg

Appendix B Mammalian septin nomenclature 351

Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. Pringle

Appendix C Septin meetings and workshops 355

Peter A. Hall and John R. Pringle

Index 361