Platelet Proteomics: Principles, Analysis, and ApplicationsISBN: 978-0-470-46337-6
Hardcover
432 pages
May 2011
This is a Print-on-Demand title. It will be printed specifically to fill your order. Please allow an additional 10-15 days delivery time. The book is not returnable.
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The purpose of the book is to introduce platelets, and their
functional role in thrombotic and cardiovascular disease,
justifying the relevance of platelet proteomics research. Focus
then shifts to the recent developments on mass spectrometry
(MS)-based proteomics. This chapter shows potential
applications for platelet proteomics not yet carried out. It
includes examples of post-translational modifications (PTMs)
analysis in platelets.
The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.