Biomarkers: In Medicine, Drug Discovery, and Environmental HealthISBN: 978-0-470-45224-0
Hardcover
648 pages
October 2010
This is a Print-on-Demand title. It will be printed specifically to fill your order. Please allow an additional 15-20 days delivery time. The book is not returnable.
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Preface xxii
Contributors xxv
1 Biomarkers: An Evolutionary Perspective 1
Michael Ferguson and Vishal Vaidya
Section I: Tools for Biomarker Discovery 5
2 Genomics 7
Weida Tong and Donna L. Mendrick
3 Proteomics for Biomarker Discovery 25
Timothy D. Veenstra
4 Metabolic Profiling for Biomarker Discovery 47
Hector C. Keun
5 The Bittersweet Promise of Glycobiology 75
Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta
Section II: Biomarkers of Injury/Disease 89
6 Biomarkers of Alzheimer's and Parkinson's Disease 91
Walter Maetzler and Daniela Berg
7 Biomarkers of Cardiac Injury 119
Anthony S. McLean and Stephen J. Huang
8 Lung Injury Biomarkers 157
Urmila P. Kodavanti
9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203
Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah
10 Biomarkers of Acute Kidney Injury 237
Frank Dieterle and Frank Sistare
11 In Search of Biomarkers for Drug-Induced Vascular Injury 281
James R. Turk
12 Biomarkers of Immunotoxicity 307
Rodney R. Dietert
13 Biomarkers in Obstetric Medicine 323
Manish Maski, Sarosh Rana and S. Ananth Karumanchi
14 Biomarkers in Cancer 355
Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses
15 Biomarkers of HIV 381
Lewis Kaufman and Michael J Ross
16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401
James A. Dykens and Yvonne Will
Section III: Technology for Biomarker Detection 423
17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425
Vincent Ricchiuti
18 Nanoscale Techniques for Biomarker Quantification 457
Madhukar Varshney, and Harold G. Craighead
19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495
Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd
Section IV: Hot Topics In Biomarker Research 517
20 Biomarkers for Environmental Exposure 519
Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards
21 Clinical Study Design in Biomarker Research 549
Orfeas Liangos and Bertrand L. Jaber
22 Statistical Issues in Biomarker Research 561
Daniel Holder and Matthew Schipper
23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581
Federico Goodsaid
24 The European Medicines Agency Approach 589
Marisa Papaluca Amati and Spiros Vamvakas
Index 595