Pain in Osteoarthritis

Preface vii

Acknowledgments ix

Contributors xi

Part I The Neuroscience of Articular Pain

1 Spinal Mechanisms Contributing to Joint Pain 3
Hans-Georg Schaible

2 Activation of Sensory Neurons in the Arthritic Joint 25
Blair D. Grubb

3 Changes in the Neural Substrate of Nociception in a Rat Derangement Model of Osteoarthritis 39
James L. Henry

4 Inflammatory Mediators and Nociception in Osteoarthritis 55
Bruce L. Kidd, Jason J. McDougall, and Julia J. Inglis

5 Phantoms in Rheumatology 73
Candida S. McCabe, Richard C. Haigh, Nicholas G. Shenker, Jenny Lewis, and David R. Blake

6 Mechanisms That Generate and Maintain Bone Cancer Pain 97
Juan Miguel Jimenez-Andrade, Monica Herrera, and Patrick W. Mantyh

7 Symmetry, T-Cells, and Neurogenic Arthritis 117
Nicholas G. Shenker, David R. Blake, Candida S. McCabe, Richard C. Haigh, and Paul I. Mapp

Part II Osteoarthritis and Pain

8 Joint Mechanics in Osteoarthritis 133
Walter Herzog, Douglas Bourne, and Aliaa Rehan Youssef

9 Neuromuscular Aspects of Osteoarthritis 157
Kenneth D. Brandt

10 Pressure-Driven Intravasation of Osseous Fat in the Pathogenesis of Osteoarthritic Pain 175
Peter A. Simkin

11 Structural Correlates of Osteoarthritis Pain: Lessons From Magnetic Resonance Imaging 185
Philip G. Conaghan

12 Evidence of Sensitization to Pain in Human Osteoarthritis 199
Gunnar Ordeberg

13 Current Perspectives on the Clinical Presentation of Joint Pain in Human Osteoarthritis 211
Paul Creamer

Part III Treatment of Osteoarthritic Pain

14 General Approach to Treating Osteoarthritic Pain: Targeting Biomechanics Inflammation and Nociception 229
David T. Felson

15 Neurobiological Mechanisms of Osteoarthritic Pain and Analgesic Treatment 233
Tuhina Neogi and Joachim Scholz

16 Exercise, Taping, and Bracing as Treatments for Knee Osteoarthritis Pain 255
Kim Louise Bennell, Michael Anthony Hunt, and Rana Shane Hinman

17 Treating Inflammation to Relieve Osteoarthritic Pain 285
David T. Felson

Index 295