Viral Oncology: Basic Science and Clinical Applications

Foreword vii

Preface xi

Contributors xiii

1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1
Rachel A. Katzenellenbogen and Denise A. Galloway

2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23
Amy Baldwin and Karl Münger

3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57
Miranda Thomas, David Pim, and Lawrence Banks

4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89
Krzysztof Reiss, Kamel Khalili, and Luis Del Valle

5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113
C. Richard Boland, Luigi Ricciardiello, and Ajay Goel

6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129
Michael J. Imperiale and Dweepanita Das

7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149
Abhilasha V. Rathi and James M. Pipas

8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165
Janet S. Butel

9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191
Natalya Baranova and Michele Carbone

10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211
Timothy M. Block and Anand S. Mehta

11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225
Mei-Hwei Chang and Ding-Shinn Chen

12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243
Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun

13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267
Donna Sir and Jing-Hsiung James Ou

14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279
Masao Matsuoka

15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295
Susan J. Marriott

16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317
Melissa Agsalda and Bruce Shiramizu

17 HIV-RELATED LYMPHOMA 337
Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini

18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351
Veenu Minhas and Charles Wood

19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377
Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger

20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409
Joseph S. Pagano

21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425
Wasim A. Dar and Bill Sugden

Index 453