Peptide and Protein Design for Biopharmaceutical ApplicationsISBN: 978-0-470-31961-1
Hardcover
306 pages
November 2009
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Peptides serve as effective drugs in the clinic today. However the
inherent drawbacks of peptide structures can limit their efficacy
as drugs. To overcome this researchers are developing new methods
to create ‘tailor-made’ peptides and proteins with
improved pharmacological properties.
Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:
- Computer modeling of peptides and proteins
- Peptidomimetics
- Design and synthesis of cyclic peptides
- Carbohydrates in peptide and protein design
- De novo design of peptides and proteins
- Medical development applications
- An extended case study – the design of insulin variants
Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.