Medical Biochemistry: Human Metabolism in Health and Disease

ACKNOWLEDGMENTS ix

THE AUTHORS xi

1 INTRODUCTION TO METABOLISM 1

2 ENZYMES 11

3 DIGESTION AND ABSORPTION 38

4 GLYCOLYSIS 58

5 PYRUVATE DEHYDROGENASE AND THE TRICARBOXYLIC ACID CYCLE 77

6 ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION 89

7 THE PENTOSE PHOSPHATE PATHWAY 102

8 GLYCOGEN 112

9 GLUCONEOGENESIS 126

10 FATTY ACID OXIDATION AND KETONES 141

11 FATTY ACID SYNTHESIS 162

12 TRIACYLGLYCEROL TRANSPORT AND METABOLISM 177

13 ETHANOL 191

14 PHOSPHOLIPIDS AND SPHINGOLIPIDS 199

15 EICOSANOIDS 218

16 GLYCOLIPIDS AND GLYCOPROTEINS 231

17 CHOLESTEROL SYNTHESIS AND TRANSPORT 246

18 STEROIDS AND BILE ACIDS 271

19 NITROGEN HOMEOSTASIS 290

20 AMINO ACIDS 305

21 SULFUR AMINO ACID METABOLISM 325

22 FOLATE AND VITAMIN B12 IN ONE-CARBON METABOLISM 335

23 PURINES AND PYRIMIDINES 351

24 HEME AND IRON 372

25 INTEGRATION OF METABOLISM 393

INDEX 411