Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune SystemsISBN: 978-0-470-09046-6
Hardcover
240 pages
December 2004
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Inflammatory bowel disease (IBD) comprises a group of idiopathic
diseases of the intestine characterized by chronic inflammation of
the bowel with periods of exacerbation and remission. Although the
exact cause of IBD remains undetermined, the condition appears to
be related to a combination of genetic and environmental factors
resulting in an aberrant activation of the mucosal immune system.
This book contains a series of interdisciplinary discussions
between clinical and basic scientists focusing on key issues such
as:
- Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival
- The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy
- The progress towards the identification of susceptibility genes and phenotype-determining genes
- The pharmacogenetics of IBD
- Mucosal immunology and therapeutic strategies stemming therefrom