Immunology: Understanding The Immune System, 2nd Edition

Preface ix

Note to Reader xi

1. Introduction to the Immune System 1

2. Cells and Organs of the Immune System 27

3. Innate Immunity 61

4. Antigens and Antibodies 105

5. Antigen-Antibody Interactions and Some Experimental Systems 139

6. The Genetics of Antibody Formation and Structure 179

7. The Major Histocompatibility Complex and Development of Immunity 213

8. The T-Cell Receptor Complex: Characterization, Diversification, Costimulatory Molecules, Thymic Selection, and T-Cell Activation 253

9. Cytokines 285

10. Cellular Interactions: Development of Effector Functions and Their Regulation 321

11. Complement 369

12. Hypersensitivities 397

13. Immunologic Tolerance and Autoimmunity 431

14. Transplantation Immunology 461

15. Tumor Immunology 489

16. Immunodeficiencies 529

17. Immunity to Microbes 561

Glossary of Commonly Used Immunologic Terms 611

Appendix: Human Cluster of Differentiation (CD) Molecules 687

Index 703